Quantitative spatial evaluation of tumor-immune interactions in the immunotherapy setting of metastatic melanoma lymph nodes.

Rachel L G Maus,Alexey A Leontovich,Raymond M Moore,Zachary Fogarty,Ruifeng Guo,Tara M Davidson,Burak Tekin, Chathu Atherton,Jill M Schimke,Betty A Dicke,Benjamin J Chen,Svetomir N Markovic

Frontiers in immunology（2022）

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摘要

Overall, this study offers a more comprehensive evaluation of immune infiltrates and spatial-immune signatures in the metastatic tumor-immune microenvironment as it informs recurrence risk following immunotherapy.

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关键词

immunotherapy,melanoma,multiplex immunofluorescence,spatial biology,tumor microenvironment

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