Isolation and characterization of head and neck cancer-derived peritumoral and cancer-associated fibroblasts.

Jiefu Zhou,Sabina Schwenk-Zieger,Gisela Kranz,Christoph Walz,Frederik Klauschen,Sharduli Dhawan,Martin Canis,Olivier Gires,Frank Haubner,Philipp Baumeister,Vera Kohlbauer

Frontiers in oncology（2022）

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摘要

Hence, matched CAFs and PtFs present in HNSCC patients are heterogeneous in their proliferation-, migration-, and angiogenesis-promoting capacity. Despite this heterogeneity, CAFs induced stronger carcinoma cell proliferation and HUVEC tube formation overall, whereas PtFs promoted migration of tumor cells more strongly.

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关键词

angiogenesis,cancer-associated fibroblasts,head and neck squamous cell carcinoma,peritumoral fibroblasts,tumor microenvironment

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