MiR-4291 stabilized the vulnerable atherosclerotic plaques by degrading the MAPK1/ERK2 in ApoE -/- mice.

Yaqiong Jin,Jingchao Lu,Fan Liu,Xiuchun Yang,Fei Chen,Jie Zhang

Annals of translational medicine（2022）

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摘要

MiR-4291 reduced the expression of MMP-2/9 by inhibiting the activity of ERK2, which in turn increased the fibrous cap thickness and stabilized the vulnerable plaques in AS.

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关键词

fibrous cap thickness,miR-4291,p-ERK1-2,vulnerable plaques

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