Reduced D 2 /D 3 Receptor Binding and Glucose Metabolism in a Macaque Model of Huntington's Disease.

Alison R Weiss,Daniele Bertoglio,William A Liguore,Kristin Brandon,John Templon,Jeanne Link,Jodi L McBride

Movement disorders : official journal of the Movement Disorder Society（2023）

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摘要

[ F]Fallypride and [ F]FDG are PET imaging biomarkers of mHTT-mediated disease progression that can be used as noninvasive outcome measures in future therapeutic studies with this AAV-mediated HD macaque model. © 2022 International Parkinson and Movement Disorder Society.

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关键词

2-[18F]fluoro-2-deoxy-d-glucose,binding potential,cortical-basal ganglia,fallypride,positron emission tomography imaging

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