Validation of a diet-induced Macaca fascicularis model of non-alcoholic steatohepatitis with dietary and pioglitazone interventions.

Raul C Camacho,David Polidori,Tao Chen,Bin Chen, Helen Han Hsu,Bin Gao, Mathieu Marella, Mariusz Lubomirski,Traymon Beavers,Javier Cabrera, Peggy Wong,Andrea R Nawrocki

Diabetes, Obesity and Metabolism（2023）

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摘要

Both weight loss induced by DSCR and treatment with pioglitazone improve the histological features of NASH in a diet-induced cynomolgus monkey model. This model provides a translational preclinical model for testing novel NASH therapies.

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关键词

NASH,caloricrestriction,cynomolgus monkey,fibrosis,nonhuman primate,pioglitazone

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