Sphingosine Kinase 2 in Stromal Fibroblasts Creates a Hospitable Tumor Microenvironment in Breast Cancer.

Cynthia Weigel,Melissa A Maczis,Elisa N D Palladino,Christopher D Green,Michael Maceyka,Chunqing Guo,Xiang-Yang Wang,Mikhail G Dozmorov,Sheldon Milstien,Sarah Spiegel

Cancer research（2023）

引用 4|浏览8

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摘要

Sphingosine kinase 2 (SphK2) facilitates the activation of stromal fibroblasts to tumor-promoting cancer-associated fibroblasts by suppressing host p53 activity, revealing SphK2 as a potential target to reprogram the TME.

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关键词

breast cancer,hospitable tumor microenvironment,stromal fibroblasts

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