Blood RNA transcripts reveal similar and differential alterations in fundamental cellular processes in Alzheimer's disease and other neurodegenerative diseases.

Carol J Huseby,Elaine Delvaux, Danielle L Brokaw,Paul D Coleman

Alzheimer's & dementia : the journal of the Alzheimer's Association（2022）

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摘要

Transcriptomics offer information about dysfunctional processes. Comparing multiple diseases will expose unique malfunctions within diseases. Blood RNA can be used ante mortem to track expression changes in neurodegenerative diseases. Protocol standardization will make public datasets compatible.

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关键词

Alzheimer's disease,Friedreich's ataxia,Huntington's disease,Lou Gehrig's disease,Parkinson's disease,amyotrophic lateral sclerosis,frontotemporal dementia,machine learning,pathway analysis,random forest classification,whole blood RNA

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