Clinical accuracy of SARS-CoV-2 rapid antigen testing in screening children and adolescents

Dear editor, recently in this journal Shamez Ladhani presented the need of verified, objective evidence of significant benefit without potential or proven harms for the implementation of COVID-19 mitigation strategies among children.(1) Besides face masking, regular use of SARS-CoV-2 rapid antigen detection tests (RDT) has been established as infection control strategy in nurseries and schools.(2) Despite this, a large-scale, real-life analysis of RDT performance among children and adolescents considering COVID-19 vaccination status and SARS-CoV-2 virus variants of concern (VOC) is still missing.(3-7)