Impaired protective role of HLA-B*57:01/58:01 in HIV-1 CRF01_AE infection: a cohort study in Vietnam

Tam Tran Thi Minh,Yuta Hikichi,Shoji Miki,Yuriko Imanari,Shigeru Kusagawa,Midori Okazaki, Thao Dang Thi Thu,Teiichiro Shiino,Saori Matsuoka,Hiroyuki Yamamoto,Jun Ohashi,William W Hall,Tetsuro Matano,Lan Anh Nguyen Thi,Ai Kawana-Tachikawa

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases（2023）

引用 0|浏览15

暂无评分

摘要

•The protective effect of HLA-B*57:01/58:01 on HIV-1 CRF01_AE infection was examined.•The protective impact is impaired against CRF01_AE infection.•TW10-specific CD8+ T cells select for T242N even in CRF01_AE with viral fitness cost.•Less non-TW10 epitope presentation may contribute to the impaired protective impact.

查看译文

关键词

Human Immunodeficiency Virus type-1,Human Leukocyte Antigen,Escape mutation, Viral fitness

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要