0multifunctional Nanoparticles For Organelle-Specific Targeted Drug Delivery In Cancer Therapy

Abstract: Successful drug delivery with a carrier into the targeted organelles (nucleus, mitochondria, lysosomes, etc.) is vital for achieving effective disease treatment. Nanoparticle (NP) based drug delivery systems (NDDSs) depend on targeted delivery and are mainly focused on cell-membrane targeting. In this review, we summarize research on multifunctional NPs with organelle-specific drug delivery. Different effective strategies are proposed for these nanoparticles functionalizing by altering their chemical composition or by functional groups grafting onto their surface for improving the ability of organelle targeting. Only when the released concentration of drugs becomes high enough will they interact with specific organelles by molecular targets to induce apoptosis of tumor cells. One of the prime goals for drug delivery research targeted is Organelle-specific delivery.