Association between late-life air pollution exposure and medial temporal lobe atrophy in older women.

Xinhui Wang,Lauren E Salminen,Andrew J Petkus,Ira Driscoll,Joshua Millstein,Daniel P Beavers,Mark A Espeland, Guray Erus,Meredith N Braskie,Paul M Thompson,Margaret Gatz,Helena C Chui,Susan M Resnick,Joel D Kaufman,Stephen R Rapp,Sally Shumaker, Mark Brown,Diana Younan,Jiu-Chiuan Chen

Alzheimer's & Dementia（2023）

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摘要

First longitudinal study on air pollution and medial temporal lobe (MTL) volume. Late-life PM and NO associated with MTL atrophy over time in older women. Heterogeneous adverse effects were observed across different subregions of the MTL. Results not differ by genotype, age, education, or cardiovascular risk factors. Adverse effects remained at low-level exposure compliant with regulatory standards.

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关键词

medial temporal lobe atrophy,medial temporal lobe,air pollution,older women,exposure

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