Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.

Rui Lu,Zhiyi He,Weikai Zhang,Yingguang Wang,Peng Cheng,Zhengtao Lv,Xuefeng Yuan,Fengjing Guo,Hongbo You,An-Min Chen,Weihua Hu

Frontiers in endocrinology（2022）

引用 10|浏览7

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摘要

The study verified that OB exhibited the chondroprotective effect by anti-inflammatory, inhibiting the PI3K/AKT/mTOR signaling pathway, and enhancing the autophagy process, indicating that OB might be a promising agent for the treatment of OA.

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关键词

PI3K/AKT/mTOR,autophagy,chondrocytes,inflammation,oroxin B,osteoarthritis

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