Effects of enrichment strategies on outcome of adrecizumab treatment in septic shock: Post-hoc analyses of the phase II adrenomedullin and outcome in septic shock 2 trial.

Dirk van Lier,Adrien Picod,Gernot Marx,Pierre-François Laterre,Oliver Hartmann, Claudia Knothe,Feriel Azibani,Joachim Struck,Karine Santos, Jens Zimmerman,Andreas Bergmann,Alexandre Mebazaa,Peter Pickkers

Frontiers in medicine（2022）

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摘要

In septic shock patients with high ADM levels, a further enrichment strategy based on cDPP3 may indicate (with all the caveats to be considered for subgroup analyses) that therapeutic efficacy is most pronounced in patients with lower cDPP3 levels.

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关键词

Adrecizumab,AdrenOSS-2,adrenomedullin,dipeptidyl peptidase 3,sepsis,septic shock

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