Interleukin-27 impairs BCG antigen clearance and T cell stimulatory potential by neonatal dendritic cells

•Interleukin-27 expression increases in neonatal dendritic cells in response to BCG.•The BCG vaccine is currently the only licensed vaccine available for tuberculosis.•BCG is commonly administered to neonates in TB endemic areas.•IL-27 limits BCG clearance by DCs and restricts interleukin-12 production.•IL-27 opposes T cell stimulation by neonatal dendritic cells.