Study of epirubicin sustained-release chemoablation in tumor suppression and tumor microenvironment remodeling.

Liangliang Meng, Zhenjun Wang, Zhonghui Hou,Hufei Wang,Xiao Zhang,Xiaobo Zhang,Xiaofeng He,Xin Zhang,Boyu Qin, Jing Li,Zhongliang Zhang,Xiaodong Xue,Yingtian Wei

Frontiers in immunology（2022）

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摘要

The combination of local injection of the chemoablation agent with anti-PD-L1 monoclonal antibody (mAb) therapy may strengthen the antitumor activity, and the use of PEG hydrogel as the drug carrier can extend the retention time of the chemoablation agent around the tumor, maintaining a long-term tumor-killing activity.

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关键词

chemoablation,drug sustained release,epirubicin (EPI),immune checkpoint inhibitor (ICI),immunotherapy,percutaneous injection,tumor microenvironment

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