Synthesis and study of the structure—antitumor activity relationship of new pyridoxine-containing structural analogs of saccharumoside-B

We synthesized a number of new derivatives of phenolic glycoside saccharumoside-B based on pyridoxine and 3-hydroxy-2-methylpyridine and studied their cytotoxicity in vitro against three normal (HEK-293, Chang Liver, MSC) and nine tumor (MCF-7, MDA-MB-231, A-498, SNB-19, M-14, NCI-H322M, HCT-115, HCT-116, PC-3) human cell lines compared with camptothecin, doxorubicin, and saccharumoside-B. The effect of the peripheral fragments of phenolic glycoside on the target activity was studied and the structure—antitumor activity relationship was established. A new efficient approach to the synthesis of saccharumoside-B was proposed.