Design and synthesis of 1‑sec/tert‑butyl-2-chloro/nitrophenylbenzimidazole derivatives: Molecular docking and in vitro evaluation against MDA-MB-231 and MCF-7 cell lines

Mar'iyah Najihah Abdullah,Shafida Abd Hamid,Salizawati Muhamad Salhimi,Nurul Awani Syazzira Jalil,Mohammad Al-Amin, Nor Saliyana Jumali

Journal of Molecular Structure（2023）

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摘要

•Two series of N‑sec/tert‑butyl‑2‑chloro/nitrophenylbenzimidazoles were synthesized.•Compounds were evaluated for activity against MDA-MB-231 and MCF-7 cell lines.•Chloro-substituted benzimidazoles generally showed better inhibitory effect.•4b9, 4b10, 4b6 and 4b8 were selective towards MCF-7 and inactive against MDA-MB-231.

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关键词

Benzimidazole,Antiproliferative,MDA-MB-231,MCF-7,Molecular docking

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