Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of Mtorc1, for the Treatment of Mtorc1-Activated Tumors.
G. Leslie Burnett,Yu C. Yang,James B. Aggen,Jennifer Pitzen, Micah K. Gliedt,Chris M. Semko,Abby Marquez,James W. Evans, Gang Wang,Walter S. Won,Aidan C. A. Tomlinson,Gert Kiss,Christos Tzitzilonis,Arun P. Thottumkara,James Cregg,Kevin T. Mellem,Jong S. Choi, Julie C. Lee,Yongyuan Zhao,Bianca J. Lee,Justin G. Meyerowitz,John E. Knox,Jingjing Jiang,Zhican Wang,David Wildes,Zhengping Wang,Mallika Singh,Jacqueline A. M. Smith,Adrian L. Gill JOURNAL OF MEDICINAL CHEMISTRY（2023）
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