Identifying transcript-level differential expression in primary human immune cells

Saraï Mola,Claudine Beauchamp,Gabrielle Boucher,Sylvie Lesage,Mohamad Karaky,Philippe Goyette,Sylvain Foisy,John D Rioux

Molecular Immunology（2023）

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摘要

•Determined genome-wide transcript-level expression in peripheral blood cells.•Over 55 % of genes detected in primary human immune cells express ≥ 2 transcripts.•Approach identified genes where ≥ 2 their transcripts have divergent expression.•Immune functions regulated by controlling expression of different protein isoforms.

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关键词

Primary human immune cells,RNA-Seq,Differential transcript expression control,Protein isoforms

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