Organic fluorescent probe for concurrent imaging and apoptosis induction in cancer cells in vivo and in vitro by utilizing endogenous hydrogen sulfide

Zhou Xu, Yan Zheng, Ranran Qiao,Shengrui Cao, Yuan Fang, Xiumei Bo,Huilong Zhu,Changjiang Ying,Ying Sun,Junnian Zheng

Chemical Engineering Journal(2022)

引用 6|浏览2
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摘要
•A bifunctional probe for concurrent imaging and apoptosis induction was reported.•The probe has negligible cytotoxicity and shown anti-interference performance.•The probe can detect H2S with high selectivity and sensitivity.•The fluorophore could inhibit MCF-7 cell proliferation with an IC50 of 10.12 μM.•The probe could use in vivo imaging and treatment of tumor-bearing nude mouse.
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关键词
Hydrogen sulfide,Fluorescent probe,Breast cancer theranostics,Endogenous signaling gas
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