Reverse causal relationship between periodontitis and shortened telomere length: Bidirectional two-sample Mendelian random analysis.

Jiaxin Hu,Jukun Song,Zhu Chen, Jing Yang,Qianhui Shi,Fuqian Jin,Qiyuan Pang, Xingtao Chang, Yuan Tian,Yi Luo,Liming Chen

Frontiers in immunology（2022）

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摘要

Our MR studies showed a reverse causal relationship, with shorten TL being linked to a higher risk of periodontitis, rather than periodontitis shorten that TL. Future research is needed to investigate the relationship between cell senescence and the disease.

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关键词

Mendelian randomization,biological aging,causality,genome-wide association studies,inflammation,periodontal disease,telomere length

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