Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19.

Rodrigo de Oliveira Formiga, Flávia C Amaral,Camila F Souza,Daniel A G B Mendes,Carlos W S Wanderley, Cristina B Lorenzini, Adara A Santos, Juliana Antônia, Lucas F Faria,Caio C Natale, Nicholas M Paula, Priscila C S Silva,Fernanda R Fonseca, Luan Aires,Nicoli Heck,Márick R Starick,Celso M Queiroz-Junior,Felipe R S Santos,Filipe R O de Souza,Vivian V Costa,Shana P C Barroso,Alexandre Morrot,Johan Van Weyenbergh,Regina Sordi,Frederico Alisson-Silva,Fernando Q Cunha,Edroaldo L Rocha,Sylvie Chollet-Martin,Maria Margarita Hurtado-Nedelec,Clémence Martin,Pierre-Régis Burgel,Daniel S Mansur,Rosemeri Maurici,Matthew S Macauley,André Báfica,Véronique Witko-Sarsat,Fernando Spiller

British journal of pharmacology（2022）

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摘要

These findings suggest that NEU1-MMP-9 interplay induces neutrophil overactivation. In vivo, it was shown that NEU may serve as a host-directed target to dampen neutrophil dysfunction during severe infections.

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关键词

COVID-19,Oseltamivir,SARS-CoV-2,Zanamivir, neutrophil,metalloproteinase-9,neuraminidase,sepsis,sialic acid

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