Genetic expression changes and pathologic findings associated with hyperhomocysteinemia in human autopsy brain tissue.

Erica M Weekman, Zach Winder,Colin B Rogers,Erin L Abner,Tiffany L Sudduth,Ela Patel,Adam J Dugan,Shuling X Fister,Brandi Wasek,Peter T Nelson,Gregory A Jicha,Teodoro Bottiglieri,David W Fardo,Donna M Wilcock

Alzheimer's & dementia (New York, N. Y.)（2022）

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摘要

Increased plasma homocysteine and older age were associated with the downregulation of inflammatory gene expression markers in association with significant glial and vascular pathology changes. Impaired immune function is a plausible mechanism by which HHcy increases cerebrovascular damage leading to impaired cognitive function.

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关键词

Alzheimer's disease,astrocytes,atherosclerosis,hyperhomocysteinemia,microglia,microhemorrhages,neuroinflammation,vascular contributions to cognitive impairment and dementia

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