Serum levels of glial fibrillary acidic protein in patients with amyotrophic lateral sclerosis.

Federico Verde,Ilaria Milone,Alessio Maranzano,Eleonora Colombo,Silvia Torre,Federica Solca,Alberto Doretti,Francesco Gentile,Arianna Manini,Ruggero Bonetti,Silvia Peverelli,Stefano Messina,Luca Maderna,Claudia Morelli,Barbara Poletti,Antonia Ratti,Vincenzo Silani,Nicola Ticozzi

Annals of clinical and translational neurology（2023）

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摘要

Our work provides neurochemical evidence of astrocyte involvement in ALS pathophysiology and particularly in the development of extra-motor manifestations (namely, cognitive - memory - impairment) and respiratory dysfunction. The negative correlation between sGFAP and eGFR has practical relevance and should not be disregarded in future investigations.

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关键词

amyotrophic lateral sclerosis,glial fibrillary acidic protein,serum

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