Selective access to fused tetrahydroquinolines via a copper-catalysed oxidative three-component annulation reaction.
Organic & biomolecular chemistry(2023)
摘要
a copper-catalyzed three-component annulation reaction, we herein report a new method for the direct and -selective construction of cyclic ether-fused tetrahydroquinolines from readily available secondary anilines, saturated five or six-membered cyclic ethers, and paraformaldehyde. The synthesis features operational simplicity, excellent step and atom efficiency, good functionality and substrate compatibility. In comparison with the reported synthetic protocols capable of synthesizing -alkyl fused tetrahydroquinolines, this newly developed chemistry allows access to both -alkyl and -aryl products. The current work complements the preparation of fused tetrahydroquinolines.
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关键词
tetrahydroquinolines,copper-catalysed,three-component
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