Use of Leishmania major parasites expressing a recombinant Trypanosoma cruzi antigen as live vaccines against Chagas disease.

Catherine W Cai, Anne O'Shea,Christopher S Eickhoff,Hongjie Guo,Warren G Lewis,Stephen M Beverley,Daniel F Hoft

Frontiers in microbiology（2022）

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摘要

Altogether, these data indicate that can stably express a antigen and induce -specific protective immunity, warranting further investigation of attenuated Leishmania parasites as vaccine.

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关键词

Chagas,leishmaniasis,live vector,parasite,vaccine

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