The O 6 -methylguanine-DNA methyltransferase (MGMT) promoter methylation status and clinical outcomes of Ewing sarcoma patients treated with irinotecan and temozolomide.

Samer Salah,Walid Naser,Omar Jaber,Yacob Saleh,Rawan Mustafa,Ramiz Abuhijlih,Fawzi Abuhijla,Taleb Ismaeel,Sameer Yaser,Iyad Sultan,Nour Mustafa,Abdelghani Tbakhi

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology（2022）

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摘要

-promoter methylation did not correlate with clinical activity or outcomes following the IT regimen for advanced ES. However, methylated predicted significantly superior PFS following initiation of the standard VDC-IE protocol.

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Ewing sarcoma,MGMT methylation,biomarkers,prognosis,survival

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