Distinct Profiles of DNA Repair Activity Define Favorable-risk Prostate Cancer Subtypes With Divergent Outcome

Nishwant Swami,Tiffany Nguyen,Ifeanyichukwu Ogobuiro,Matthew Abramowitz,Fallon Chipidza,Elai Davicioni,Karthik Meiyappan,Alan Dal Pra,Paul L Nguyen,Alan Pollack,Sanoj Punnen,Brandon A Mahal,Mohammed Alshalalfa

Clinical Genitourinary Cancer（2023）

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摘要

•This study first shows that high DNA repair activity is associated with high-risk prostate cancer.•Within low-risk prostate tumors, higher DNA repair activity is associated with poor outcome.•Within low-risk prostate patients who are candidates for active surveillance, high DNA repair activity defines a molecularly and clinically distinct subtype.

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关键词

Neoplasm grading,Prostatic neoplasms,Prognostic signatures,Transcriptomics,DNA-repair

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