Intra-uterine diazepam exposure decreases the number of catecholaminergic and serotoninergic neurons of neonate rats

Carlos Aparecido da Silva Junior,Danuzia A Marques,Luís Gustavo A Patrone,Vivian Biancardi,Kênia C Bícego,Luciane H Gargaglioni

Neuroscience Letters（2023）

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摘要

•Anxiety affects pregnant women, and they are commonly treated with diazepam.•Diazepam interacts with fetus’ GABAergic system, yet outcomes are unknown.•GABA is an important neurotransmitter for maturation of the monoaminergic system.•P12–13 rats prenatally exposed to diazepam had less monoaminergic neurons.•Neuroanatomical defects in the monoaminergic system may affect breathing control.

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关键词

Benzodiazepine,Catecholamine,Critical period,Serotonin,GABA,Breathing

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