Nobiletin inhibits breast cancer cell migration and invasion by suppressing the IL-6-induced ERK-STAT and JNK-c-JUN pathways

Yuan Wu,Qiong Li,Ling-ling Lv,Jing-xian Chen,Hai-feng Ying,Ming Ruan,Wen-hua Zhu,Jia-yue Xu, Chen-yiyu Zhang,Kai-yuan Zhang,Yuan-biao Guo,Wei-rong Zhu,Lan Zheng

Phytomedicine（2022）

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摘要

Nobiletin inhibited liver metastasis of breast cancer by downregulating the ERK-STAT and JNK-c-JUN pathways, and its safety and efficacy were verified, indicating the potential of nobiletin as an anticancer agent.

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关键词

Nobiletin,Breast cancer,ERK-STAT and JNK-c-JUN signaling,Anti-invasion and anti-migration,Citri renetulatae pericarpium

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