Optimization of the operating point of an axial impeller without central shaft in blood flow

This article covers the obtention of the mathematical models for the volumetric strain, pressure difference, and flow responses of an axial impeller designed for a ventricular assist device. This impeller has a novel geometry that requires the validation of its behavior at the structural and fluid dynamics level. Based on the specifications required for the application, the optimal operating point of the impeller is obtained in terms of its rotational velocity, material, and blood flow output velocity. Likewise, the range of values of the factors that meet the specifications is obtained. Among the materials included are Platinum and the biocompatible polymer Peek. The analysis is carried out by means of a full factorial design of experiments, with results previously obtained using simulation tools. Obtaining the mathematical models is carried out by debugging the input factors and their interactions.