Mid-infrared nanospectroscopy of individual DNA-binding protein oligomers

A. Intze, M. E. Temperini, R. Polito, E. Zacco,G. G. Tartaglia,A. Pastore,M. Ortolani,V Giliberti

2022 47TH INTERNATIONAL CONFERENCE ON INFRARED, MILLIMETER AND TERAHERTZ WAVES (IRMMW-THZ 2022)（2022）

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摘要

Photothermal expansion nanospectroscopy with a tunable mid-infrared quantum cascade laser is employed to acquire the infrared nanospectroscopy spectra of individual oligomers of a DNA-binding protein relevant for neurological diseases. Oligomers down to 100 nm diameter and 10 nm thickness are targeted leveraging on the high lateral resolution provided by the nanospectroscopy approach.

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关键词

neurological diseases,100 nm diameter,10 nm thickness,nanospectroscopy approach,individual DNA-binding protein oligomers,photothermal expansion nanospectroscopy,tunable mid-infrared quantum cascade laser,infrared nanospectroscopy spectra,individual oligomers,DNA-binding protein relevant,size 10.0 nm,size 100.0 nm

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