Simplified prepared silver nanoparticles for ultra-sensitive enhanced Raman spectroscopy substrate

Rapidly nondestructive detection technologies play an essential role in industry of food, petro-chemical and aerospace. Herein, assembled Ag nanoparticles with average diameter of 67 nm were successfully fabricated as an active SERS substrate through a modified polyol method. Rhodamine 6G (R6G, target–molecular) and Ag NPs were mixed directly, achieving an ultra-high sensitive SERS substrate with a high R6G limiting resolution of 10 −12 and a superior Enhancement Factor (EF) up to 2.2 × 10 9 . Besides, the uniformity of R6G’s Raman intensity was demonstrated, which implies that the substrate emerges a potential value in the areas of medicine, food safety and biotechnology.