COVID-19 compromises iron homeostasis: Transferrin as a target of investigation

Ana Carolina Macedo Gaiatto, Thaciane Alkmim Bibo,Nicolle de Godoy Moreira,Joyce Regina Santos Raimundo,Beatriz da Costa Aguiar Alves,Thaís Gascón, Samantha Sanches Carvalho,Edimar Cristiano Pereira,Fernando Luiz Affonso Fonseca,Glaucia Luciano da Veiga

Journal of Trace Elements in Medicine and Biology（2023）

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摘要

COVID-19 causes changes in several iron cycle pathways, with iron and ferritin levels being markers that reflect the state and evolution of infection, as well as the prognosis of the disease. The increased expression of the transferrin receptor gene suggests increased iron internalization and the mimicry of hepcidin action by SARS-CoV-2, reduces iron export via ferroportin, which would explain the low circulating levels of iron by intracellular trapping.

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Coronavirus,Iron,Ferritin,Hepcidin and transferrin receptor

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