DNA framework carriers with asymmetric hydrophobic drug patterns for enhanced cellular cytotoxicity.

Yan Zhao,Linjie Guo,Shuting Cao,Mo Xie,Hongzhen Peng,Jiang Li,Shihua Luo,Lan Ma,Lihua Wang

Chemical communications (Cambridge, England)（2023）

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摘要

We devise a class of amphiphilic drug complexes by programming hydrophobic drug patterns (HDPs) on DNA frameworks. We investigate the effect of HDPs on cellular uptake efficiency and drug potency. We achieve enhanced cytotoxicity against tumor cells by using an asymmetric HDP.

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关键词

asymmetric hydrophobic drug patterns,cytotoxicity,dna

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