Evidence of Filamin A loss of solubility at the prodromal stage of neuropathologically-defined Alzheimer's disease.
Frontiers in aging neuroscience(2022)
摘要
We observed opposite level changes between insoluble and soluble FLNA in prodromal AD. As this stage coincides with the appearance of cognitive symptoms, this may be a key event in the transition from preclinical to prodromal AD. Insoluble FLNA could be useful to identify prodromal AD among subjects with an MCI, indicating that it might be a hallmark of prodromal AD.
更多查看译文
关键词
Alzheimer’s disease,Filamin A,neuropathology,post-mortem,taupathy
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要