Dissecting the impact of molecular T-cell HLA mismatches in kidney transplant failure: A retrospective cohort study.

William Lemieux, David Fleischer,Archer Yi Yang,Matthias Niemann,Karim Oualkacha,William Klement,Lucie Richard,Constantin Polychronakos,Robert Liwski,Frans Claas,Howard M Gebel,Paul A Keown,Antoine Lewin,Ruth Sapir-Pichhadze

Frontiers in immunology（2022）

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摘要

In this study, we identified subsets of TcEMMs highly predictive of DCGF and profiles of co-expressed mismatches. Experimental verification of these TcEMMs determining immune responses and how they may interact with EMM as predictors of transplant outcomes would justify their consideration in organ allocation schemes and for modifying immunosuppression regimens.

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关键词

PIRCHE-II,death-censored graft failure,feature selection,human leukocyte antigens,network analysis

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