Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells.

Dehan Comez,Jacqueline Glenn,Stephanie M Anbuhl,Raimond Heukers,Martine J Smit,Stephen J Hill,Laura E Kilpatrick

Frontiers in immunology（2022）

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摘要

EGFR targeting nanobodies are powerful tools for studying the role of the EGFR in health and disease and allow real time quantification of ligand binding and distinct ligand induced conformational changes.

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关键词

BRET,EGFR,NanoBiT,fluorescence,nanobody

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