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排名必读论文期刊顶会热点AI 简史溯源树小脉星探人才迁徙塔尖人才国防情报追踪开源工具智慧手语
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Strategic white matter hyperintensity locations for cognitive impairment: A multicenter lesion-symptom mapping study in 3525 memory clinic patients.

Mirthe Coenen,Hugo J Kuijf,Irene M C Huenges Wajer,Marco Duering,Frank J Wolters,Evan F Fletcher,Pauline M Maillard,Frederik Barkhof,Josephine Barnes,Thomas Benke,Jooske M F Boomsma,Christopher P L H Chen,Peter Dal-Bianco,Anna Dewenter,Christian Enzinger,Michael Ewers,Lieza G Exalto,Nicolai Franzmeier,Onno Groeneveld,Saima Hilal,Edith Hofer, Dineke L Koek,Andrea B Maier,Cheryl R McCreary,Catarina S Padilla,Janne M Papma,Ross W Paterson,Yolande A L Pijnenburg,Anna Rubinski,Reinhold Schmidt,Jonathan M Schott,Catherine F Slattery,Eric E Smith,Rebecca M E Steketee,Carole H Sudre,Esther van den Berg,Wiesje M van der Flier,Narayanaswamy Venketasubramanian,Meike W Vernooij,Xu Xin,Charles DeCarli,Geert Jan Biessels,J Matthijs Biesbroek

Alzheimer's & dementia : the journal of the Alzheimer's Association（2022）

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摘要
We analyzed white matter hyperintensities (WMH) in 3525 memory clinic patients from 11 cohorts The impact of WMH on cognition depends on location We identified four strategic white matter tracts A single strategic WMH score was derived from these four strategic tracts The strategic WMH score was an independent determinant of four cognitive domains.
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关键词
cognitive impairment,lesion symptom mapping,location,memory clinic patients,white matter hyperintensities
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