Effect of a high-fat diet and leptin on STAT3 phosphorylation in hippocampal astrocytes.

V Naranjo,Beatriz Merino,N Del Olmo,L M Frago,J A Chowen,M Ruiz-Gayo, Victoria Cano González

Neuroreport（2023）

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摘要

Our data show that regular intake of HFD enhances STAT3 signaling in CA1/CA3 astrocytes, an effect that could be linked to the increase of leptin triggered by HFD. The increase of pSTAT3 might be integral to homeostatic mechanisms aimed at maintaining hippocampus function.

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关键词

astrocyte,diet,high-fat,hippocampus,leptin

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