Quantifying the changes in the tumour vascular micro-environment in spinal metastases treated with stereotactic body radiotherapy - a single arm prospective study.

Balamurugan Vellayappan,Dennis Cheong, Salil Singbal,Jeremy Tey,Yu Yang Soon,Cheng Nang Leong,Alvin Wong,Sein Lwin,Chau Hung Lee, Pravin Periasamy,Simon Lo,Naresh Kumar

Radiology and oncology（2022）

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摘要

Tumour vascular micro-environment (measured by various metrics) showed a general trend towards downregulation post-SBRT. It is likely that vascular-mediated cell killing contributes to excellent local control rates seen with SBRT. Future studies should evaluate the effect of SBRT on primary-specific spinal metastases (e.g., renal cell carcinoma).

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关键词

DCE-MRI,endothelial apoptosis,spine metastases,stereotactic body radiotherapy

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