Hexokinase inhibitor 2-deoxyglucose coordinates citrullination of vimentin and apoptosis of fibroblast-like synoviocytes by inhibiting HK2 /mTORC1-induced autophagy

Hao Xian,Yating wang,Xiurong Bao, Hanmeng Zhang,Fang Wei,Yining Song,Yumeng Wang,Yingmei Wei,Ying Wang

International Immunopharmacology（2022）

引用 2|浏览6

暂无评分

摘要

•2-DG reduced cVIM and increased apoptosis by inhibiting autophagy of fibroblast-like synoviocytes.•2-DG decreased HK2 binds to mTORC1 in FLS.•HK2 knockdown reduced cVIM and promote apoptosis by inhibiting autophagy in FLS.•HK2 knockdown activated mTORC1 pathway in FLS.

查看译文

关键词

Rheumatoid arthritis,Synoviocytes,Apoptosis,Autophagy,Hexokinase,Citrullinated vimentin

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要