Polyoxygenated Terpenoids and Polyketides from the Roots of Flueggea virosa and Their Inhibitory Effect against SARS-CoV-2-Induced Inflammation.

Six new polyoxygenated terpenoids, podovirosanes A-F (-), and two known polyketides ( and ) were isolated from the roots of . Their structures, along with absolute configurations, were deduced using spectroscopic analysis as well as computational calculations, including TDDFT calculation of ECD spectra and GIAO NMR calculations combined with DP4+ probability analysis. Compounds , , , and were found to reduce the phosphorylation levels of NF-B p65 in SARS-CoV-2 pseudovirus-stimulated PMA-differentiated THP-1 cells.