CDK4/6 Inhibition Enhances the Efficacy of Standard Chemotherapy Treatment in Malignant Pleural Mesothelioma Cells.

Rita Terenziani,Maricla Galetti,Silvia La Monica,Claudia Fumarola,Silvia Zoppi,Roberta Alfieri,Graziana Digiacomo,Andrea Cavazzoni,Delia Cavallo,Massimo Corradi,Marcello Tiseo,Pier Giorgio Petronini,Mara Bonelli

Cancers（2022）

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摘要

Our results demonstrated the therapeutic potential of CDK4/6 inhibitors in combination with chemotherapy for the treatment of MPM and are consistent with the recent positive results in the MiST2 arm in abemaciclib-treated patients.

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关键词

CDK4/6 inhibitors,abemaciclib,chemotherapy,malignant pleural mesothelioma,senescence

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