Germline findings in patients with advanced malignancies screened with paired blood–tumour testing for personalised treatment approaches

•Significant amount of relevant germline variants is detected by blood-tumour testing.•Carriers do not always fulfil clinical criteria for cancer predisposition.•Blood–Tumour testing identifies novel links between cancer predisposition genes and cancer types.•Family-specific screening strategies are required when cancer predisposition genes are found in atypical tumours.