Increased functional connectivity between nucleus basalis of Meynert and amygdala in cognitively intact elderly along the Alzheimer’s continuum

Qingze Zeng,Tiantian Qiu,Kaicheng Li,Xiao Luo,Shuyue Wang,Xiaopei Xu,Xiaocao Liu,Luwei Hong,Jixuan Li,Peiyu Huang,Minming Zhang

NeuroImage: Clinical（2022）

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摘要

•Functional change of basal forebrain occurred in early preclinical stage of AD.•Higher AD pathologic burden correlated to increased FC between NBM and amygdala.•FC between NBM and amygdala was associated with memory function.

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关键词

Alzheimer’s disease continuum,AT(N) classification system,Cognitively intact elderly,Basal forebrain cholinergic system,Functional connectivity

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