In silico high-throughput screening system for AKT1 activators with therapeutic applications in sepsis acute lung injury.

Ziyi Wang,Xuesong Wang,Zhe Guo,Haiyan Liao,Yan Chai,Ziwen Wang,Zhong Wang

Frontiers in cellular and infection microbiology（2022）

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摘要

Small-molecule compound 7460-0250 was successfully screened and confirmed as a highly selective AKT1 activator, which is a critical target in the development of new therapeutics for SALI.

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关键词

AKT1,HTS - high throughput satellite,apoptosis,lung injury,sepsis

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