Low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol measurement in Familial Dysbetalipoproteinemia

Britt E Heidemann,Charlotte Koopal,Jeanine E Roeters van Lennep,Erik S Stroes,Niels P Riksen,Monique T Mulder,Leonie C van Vark-van der Zee,Dee M Blackhurst,Frank L J Visseren,A David Marais

Clinica Chimica Acta（2023）

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摘要

•For this study data from a randomized trial performed in 28 patients with FD were used.•Friedewald, Martin-Hopkins, direct assay and gels to determine LDL-C were compared to UC.•All methods over- or underestimated LDL-C concentrations compared to UC.•UC probably overestimates LDL-C concentrations as well.•Non-HDL-C measured by standard assays performed well compared to non-HDL-C by UC.

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关键词

Familial Dysbetalipoproteinemia,Type III hyperlipoproteinemia,Low-density lipoprotein,Non-high-density lipoprotein,Cholesterol,FRIEDEWALD,Martin-Hopkins,Direct homogeneous assay,Polyacrylamide gels,Density gradient ultracentrifugation,Treatment goal

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