A bias of Asparagine to Lysine mutations in SARS-CoV-2 outside the receptor binding domain affects protein flexibility.

Jennifer C Boer,Qisheng Pan,Jessica K Holien,Thanh-Binh Nguyen,David B Ascher,Magdalena Plebanski

Frontiers in immunology（2022）

引用 3|浏览6

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摘要

This study emphasizes the importance of understanding how specific N to K mutations outside of the RBD region affect SARS-CoV-2 conformational changes and the need for neutralizing antibodies for Omicron to target a subset of conformationally dependent B cell epitopes.

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关键词

Omicron,SARS-CoV-2,infectiousness,molecular modelling,mutation

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