A song of AAs and fire: divergent sex-dependent renal inflammatory mechanisms in hypertensive SLE mice

Editorial FocusA song of AAs and fire: divergent sex-dependent renal inflammatory mechanisms in hypertensive SLE miceMadeline M. Gauthier, Sara AlMarabeh, and Christopher T. BanekMadeline M. GauthierDepartment of Physiology, University of Arizona Health Sciences Center, Tucson, Arizona, Sara AlMarabehDepartment of Physiology, University of Arizona Health Sciences Center, Tucson, Arizona, and Christopher T. BanekDepartment of Physiology, University of Arizona Health Sciences Center, Tucson, ArizonaPublished Online:22 Dec 2022https://doi.org/10.1152/ajpheart.00679.2022This is the final version - click for previous versionMoreSectionsFull TextPDF (261 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat REFERENCES1. Munguia-Realpozo P, Mendoza-Pinto C, Sierra Benito C, Escarcega RO, Garcia-Carrasco M, Mendez Martinez S, Etchegaray Morales I, Galvez Romero JL, Ruiz-Arguelles A, Cervera R. Systemic lupus erythematosus and hypertension. Autoimmun Rev 18: 102371, 2019. doi:10.1016/j.autrev.2019.102371. Crossref | PubMed | ISI | Google Scholar2. Petri M. Epidemiology of systemic lupus erythematosus. Best Pract Res Clin Rheumatol 16: 847–858, 2002. doi:10.1053/berh.2002.0259. Crossref | PubMed | ISI | Google Scholar3. Chaudhari S, D'Souza BM, Morales JY, Young-Stubbs CM, Shimoura CG, Ma R, Mathis KW. Renal TLR-7/TNF-alpha pathway as a potential female-specific mechanism in the pathogenesis of autoimmune-induced hypertension. Am J Physiol Heart Circ Physiol 323: H1331–H1342, 2022. doi:10.1152/ajpheart.00286.2022.Link | Google Scholar4. Evans LC, Petrova G, Kurth T, Yang C, Bukowy JD, Mattson DL, Cowley AW. Increased perfusion pressure drives renal T-cell infiltration in the Dahl salt-sensitive rat. Hypertension 70: 543–551, 2017. doi:10.1161/HYPERTENSIONAHA.117.09208. Crossref | PubMed | ISI | Google Scholar5. Sandberg K, Ji H. Sex differences in primary hypertension. Biol Sex Differ 3: 7, 2012. doi:10.1186/2042-6410-3-7. Crossref | PubMed | ISI | Google Scholar6. Venegas-Pont M, Manigrasso MB, Grifoni SC, LaMarca BB, Maric C, Racusen LC, Glover PH, Jones AV, Drummond HA, Ryan MJ. Tumor necrosis factor-alpha antagonist etanercept decreases blood pressure and protects the kidney in a mouse model of systemic lupus erythematosus. Hypertension 56: 643–649, 2010. doi:10.1161/HYPERTENSIONAHA.110.157685. Crossref | PubMed | ISI | Google Scholar7. Gordon C, Ranges GE, Greenspan JS, Wofsy D. Chronic therapy with recombinant tumor necrosis factor-alpha in autoimmune NZB/NZW F1 mice. Clin Immunol Immunopathol 52: 421–434, 1989. doi:10.1016/0090-1229(89)90157-8. Crossref | PubMed | Google Scholar8. Banek CT, Gauthier MM, Van Helden DA, Fink GD, Osborn JW. Renal inflammation in DOCA-salt hypertension. Hypertension 73: 1079–1086, 2019. doi:10.1161/HYPERTENSIONAHA.119.12762. Crossref | PubMed | ISI | Google Scholar9. Mathis KW, Venegas-Pont M, Flynn ER, Williams JM, Maric-Bilkan C, Dwyer TM, Ryan MJ. Hypertension in an experimental model of systemic lupus erythematosus occurs independently of the renal nerves. Am J Physiol Regul Integr Comp Physiol 305: R711–R719, 2013. doi:10.1152/ajpregu.00602.2012. Link | ISI | Google Scholar10. Mathis KW, Venegas-Pont M, Masterson CW, Wasson KL, Ryan MJ. Blood pressure in a hypertensive mouse model of SLE is not salt-sensitive. Am J Physiol Regul Integr Comp Physiol 301: R1281–R1285, 2011. doi:10.1152/ajpregu.00386.2011. Link | ISI | Google Scholar Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Related ArticlesRenal TLR-7/TNF-α pathway as a potential female-specific mechanism in the pathogenesis of autoimmune-induced hypertension 06 Dec 2022American Journal of Physiology-Heart and Circulatory Physiology More from this issue > Volume 324Issue 1January 2023Pages H82-H84 Crossmark Copyright & PermissionsCopyright © 2023 the American Physiological Society.https://doi.org/10.1152/ajpheart.00679.2022PubMed36487187History Received 1 December 2022 Accepted 7 December 2022 Published online 22 December 2022 Published in print 1 January 2023 Keywordshypertensionnephritissex differencessystemic lupus erythematosus Metrics